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GenieFluor 647 Anti-Human CD196/CCR6 Antibody [G034E3] (AGEL3365)

SKU:
AGEL3365
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG2b, k
Clone:
G034E3
Conjugation:
AF647
€269 - €829
Frequently bought together:

Description

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GenieFluor 647 Anti-Human CD196/CCR6 Antibody [G034E3]

The GenieFluor 647 Anti-Human CD196 CCR6 Antibody (G034E3) is a powerful tool for researchers studying the CD196 CCR6 protein, a key player in immune cell migration and inflammation regulation. This antibody, raised against human samples, exhibits high specificity and sensitivity in detecting CD196 CCR6 expression in various cell types. Validated for use in immunofluorescence and flow cytometry applications, it allows for precise visualization and analysis of CD196 CCR6 distribution and expression levels.CD196 CCR6, also known as a chemokine receptor, functions as a receptor for specific chemokines involved in immune cell recruitment to sites of inflammation.

Its role in immune response modulation and cell trafficking makes it a critical target for research in immunology, inflammation, and infectious diseases. By understanding the mechanisms underlying CD196 CCR6 signaling, researchers aim to develop targeted therapies for conditions such as inflammatory disorders, autoimmune diseases, and infectious pathologies.Dive into the intricate world of immune cell trafficking and inflammation regulation with the GenieFluor 647 Anti-Human CD196 CCR6 Antibody (G034E3) and unravel the complexities of immune system modulation in health and disease.

Product Title:GenieFluor 647 Anti-Human CD196/CCR6 Antibody [G034E3]
SKU:AGEL3365
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G034E3
Synonyms:CKRL3; CMKBR6; GPR29; STRL22;GPRCY4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:Genie Fluor 647 Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P51684
Gene ID:1235
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

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