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GenieFluor 488 Anti-Mouse CD18 Antibody [M18/2] (AGEL3147)

SKU:
AGEL3147
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
M18/2
Conjugation:
AF488
€199 - €459
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD18 Antibody [M18/2]

The GenieFluor 488 Anti-Mouse CD18 Antibody (M18/2) is a powerful tool designed for the detection and analysis of the CD18 protein in mouse samples. This antibody, developed by Assay Genie, offers high reactivity and specificity for CD18, a crucial cell surface molecule involved in immune cell adhesion and migration.CD18, also known as integrin beta-2, plays a key role in various immune processes, including leukocyte trafficking and activation. Dysregulation of CD18 expression or function has been associated with inflammatory disorders, autoimmune diseases, and impaired immune responses. By targeting CD18, researchers can gain insights into the mechanisms underlying these conditions and potentially identify therapeutic targets.

The GenieFluor 488 Anti-Mouse CD18 Antibody (M18/2) is an essential tool for immunology and inflammation research, enabling the visualization and quantification of CD18 expression in different cell types and tissues. With its high specificity and sensitivity, this antibody offers reliable results in techniques such as flow cytometry, immunofluorescence, and immunohistochemistry, paving the way for advancements in understanding immune system dynamics and disease pathology in preclinical and translational studies.

Product Title:GenieFluor 488 Anti-Mouse CD18 Antibody [M18/2]
SKU:AGEL3147
Size:25µg, 100µg
Clone No:M18/2
Synonyms:Integrin beta-2;Itgb2;Cell surface adhesion glycoproteins LFA-1/CR3/p150+95 subunit beta;Complement receptor C3 subunit beta;CD18;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P11835
Gene ID:16414
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD18 is a 95 kD protein, also known as integrin β2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen.

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