The GenieFluor 488 Anti-Human CD1a Antibody (OKT-6) offered by AssayGenie is a powerful tool for research involving CD1a, a cell surface antigen primarily found on dendritic cells and certain T-cell subsets. This monoclonal antibody, OKT-6, specifically targets the CD1a protein and is well-suited for use in immunofluorescence and flow cytometry applications. CD1a is involved in antigen presentation and T-cell activation, making it a key player in immune responses and tolerance mechanisms. The ability to target and detect CD1a with precision is crucial for understanding the role of this molecule in various immune processes, such as immune surveillance, tolerance induction, and autoimmune diseases.
Researchers studying immune cell dynamics, antigen presentation, and T-cell activation will find the GenieFluor 488 Anti-Human CD1a Antibody (OKT-6) invaluable in their experimental work. With its high specificity and sensitivity, this antibody enables detailed characterization and visualization of CD1a-expressing cells, facilitating deeper insights into immune system function and dysfunction.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P06126
Gene ID:
909
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD1a is a 49 kD member of the immunoglobulin superfamily also known as T6 and R4. It is a type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with β2-microglobulin. CD1a plays a role in non-peptide glycolipid antigen presentation to CD1-restricted T cells. It is expressed on cortical double positive and single positive thymocytes, Langerhans cells, and dendritic cells. In addition to antigen presentation, CD1a has been implicated in thymic T cell development.