The Gag Monoclonal Antibody (PACO34642) is a powerful tool for researchers studying retrovirus proteins, particularly the Gag protein involved in viral assembly and maturation. This antibody, produced in mice, is highly specific for Gag and has been validated for use in various applications including ELISA, immunofluorescence, and immunoprecipitation.The Gag protein is a key component in the replication cycle of retroviruses, making it an important target for antiviral drug development and understanding viral pathogenesis.
By detecting and analyzing Gag expression, researchers can gain insights into the mechanisms of retrovirus assembly and identify potential therapeutic targets.With its high specificity and versatility, the Gag Monoclonal Antibody (PACO34642) is a valuable tool for advancing research in virology, immunology, and infectious diseases. Its ability to detect Gag protein in various experimental settings makes it an essential reagent for studying retrovirus biology and developing strategies to combat retroviral infections.
Antibody Name:
gag Antibody (PACO34642)
Antibody SKU:
PACO34642
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Moloney murine leukemia virus
Immunogen:
Recombinant Moloney murine leukemia virus Gag polyprotein protein (216-478AA)
Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably link the viral protein to the host ESCRT pathway and facilitate release.Matrix protein p15 targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex.Capsid protein p30 forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex.Nucleocapsid protein p10 is involved in the packaging and encapsidation of two copies of the genome. Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome. This binding is dependent on genome dimerization.
Synonyms:
Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10-Gag (NC-gag)], gag
UniProt Protein Function:
Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably link the viral protein to the host ESCRT pathway and facilitate release.
