The GAD2 Antibody (PAC023107) is a valuable tool for researchers studying the GAD2 protein, which plays a key role in neurotransmitter signaling in the central nervous system. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunofluorescence.GAD2, also known as glutamic acid decarboxylase 2, is essential for the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA), which is involved in the regulation of neuronal excitability. Dysregulation of GAD2 expression has been implicated in neurological disorders such as epilepsy, schizophrenia, and Parkinson's disease, making it an important target for research in the field of neuroscience.
By using the GAD2 Antibody, researchers can accurately detect and quantify GAD2 expression in different cell types and tissues, providing valuable insights into the role of this protein in normal brain function and disease pathology. This antibody is a valuable tool for advancing our understanding of the molecular mechanisms underlying neurological disorders and developing targeted therapies for these conditions.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from mouse brain cells, using GAD1/2 antibody.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using GAD1/2 antibody.
Background:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
