The FXYD domain-containing ion transport regulator 7 (FXYD7) Polyclonal Antibody (CAB14895) is a powerful tool for studying the role of FXYD7 in ion transport regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the FXYD7 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for research in physiology and disease mechanisms.FXYD7, a member of the FXYD family of ion transport regulators, is known to modulate the activity of Na+/K+-ATPase pumps, which are crucial for maintaining ion gradients across cell membranes.
Dysregulation of FXYD7 has been implicated in various pathological conditions, including cardiovascular disease, renal disorders, and certain cancers. By studying the mechanisms of FXYD7, researchers can gain insights into the pathophysiology of these diseases and potentially identify new therapeutic targets for intervention.The FXYD7 Polyclonal Antibody offers a reliable tool for investigating the function and regulation of FXYD7 in cellular processes and disease states. Its specificity and sensitivity make it a valuable asset for studies aimed at understanding ion transport regulation and its implications for human health.
Product Name:
FXYD7 Rabbit Polyclonal Antibody
SKU:
CAB14895
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human FXYD7 (NP_071289.1).
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]
Purification Method:
Affinity purification
Gene ID:
53822
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FXYD7 Rabbit pAb (CAB14895) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
