The FRMD5 Polyclonal Antibody (PAC046726) is a valuable tool for researchers studying FRMD5, a protein involved in cell adhesion and migration. This antibody, produced in rabbits, shows high specificity for human samples and has been validated for use in Western blot applications. By binding to the FRMD5 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a versatile tool for studies in cell biology and cancer research.FRMD5 is a key player in cell signaling pathways that regulate cell movement and adhesion, making it a potential target for therapies aimed at controlling metastasis in cancer and other diseases.
Its role in cell migration and invasion suggests that understanding its function could lead to new insights into the mechanisms of disease progression. The FRMD5 Polyclonal Antibody is a valuable resource for researchers investigating the role of FRMD5 in cellular processes and disease development.
Western blot. All lanes: FRMD5 antibody at 16 µg/ml. Lane 1: Mouse kidney tissue. Lane 2: Mouse heart tissue. Lane 3: Mouse skeletal muscle tissue. Lane 4: Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 66, 64 kDa. Observed band size: 65 kDa..
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO46726 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human glioma using PACO46726 at dilution of 1:100.
Synonyms:
FERM domain-containing protein 5, FRMD5
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
