The FPR3 Antibody (PAC053018) is a polyclonal antibody designed for research involving FPR3, a G protein-coupled receptor known for its role in immune response regulation and chemotaxis. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for immunology studies and drug development research.FPR3 is a key player in the immune system, regulating the recruitment and activation of immune cells in response to infection or injury. Its involvement in inflammatory processes and tumor progression makes it a target of interest in various fields, including cancer research and drug discovery.
The FPR3 Antibody enables accurate detection and analysis of FPR3 protein levels in cell samples, providing valuable insights into its function and potential as a therapeutic target.By utilizing the FPR3 Antibody in experiments such as Western blotting, researchers can further explore the mechanisms by which FPR3 influences immune responses and disease pathology. Its reliable performance and specificity make it a valuable tool for advancing our understanding of FPR3 biology and identifying novel strategies for treating immune-related disorders and cancer.
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO53018 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO53018 at dilution of 1:100 and Cy3-congugated Goat Anti-Rabbit IgG.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO53018 at dilution of 1:100.
Background:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
FPR3: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Receptor, GPCR; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 19q13.3-q13.4Cellular Component: plasma membraneBiological Process: cell motility; signal transduction
