FMO3 Rabbit Polyclonal Antibody (CAB1901)
- SKU:
- CAB1901
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | FMO3 Rabbit Polyclonal Antibody |
SKU: | CAB1901 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 263-532 of human FMO3 (NP_001002294.1). |
Sequence: | RFKH ENYG LMPL NGVL RKEP VFND ELPA SILC GIVS VKPN VKEF TETS AIFE DGTI FEGI DCVI FATG YSFA YPFL DESI IKSR NNEI ILFK GVFP PLLE KSTI AVIG FVQS LGAA IPTV DLQS RWAA QVIK GTCT LPSM EDMM NDIN EKME KKRK WFGK SETI QTDY IVYM DELS SFIG AKPN IPWL FLTD PKLA MEVY FGPC SPYQ FRLV GPGQ WPGA RNAI LTQW DRSL KPMQ TRVV GRLQ KPCF FFHW LKLF AIPI LLIA VFLV LT |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:10 - 1:100 |
Synonyms: | TMAU; FMOII; dJ127D3.1; FMO3 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Microsome membrane. |
Calculated MW: | 60kDa |
Observed MW: | 68kDa |
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.
Purification Method: | Affinity purification |
Gene ID: | 2328 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |