The FGD2 Polyclonal Antibody (PACO09280) is a valuable tool for researchers studying FGD2, a protein involved in cell signaling pathways and actin cytoskeleton organization. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the FGD2 protein, this antibody allows for the detection and analysis of FGD2 in various cell types, making it ideal for investigations in cell biology and signal transduction research.FGD2 is known for its role in regulating cell migration, adhesion, and invasion, making it a key player in processes such as cancer metastasis and wound healing.
Understanding the function of FGD2 can provide valuable insights into these cellular processes and potentially lead to the development of targeted therapies for diseases related to abnormal cell movement and invasion.Overall, the FGD2 Polyclonal Antibody is a powerful tool for researchers looking to unravel the intricate mechanisms of FGD2 and its implications in various physiological and pathological conditions. Its specificity and reliability make it a valuable asset for advancing research in cell biology, cancer biology, and beyond.
FYVE, RhoGEF and PH domain containing 2;FGD2;FLJ00048;FLJ40929;MGC71330;ZFYVE4 ;
UniProt Protein Function:
FGD2: an endosome and ruffle membrane-associated guanine nucleotide exchange factor (GEF) that activates CDC42, a small G protein of the Rho-subfamily. Interacts with RAB6A bound to GTP. Activates JNK1 via CDC42 but not RAC1. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 6p21.2Cellular Component: cytoplasm; cytosol; Golgi apparatus; lamellipodium; ruffleMolecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity; small GTPase bindingBiological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; positive regulation of apoptosis; regulation of cell shape; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
