The FBXW4 Polyclonal Antibody (CAB8149) is specifically designed for research involving FBXW4, a protein involved in the regulation of cell cycle progression and protein degradation. The antibody is produced in rabbits and has high reactivity with human samples, making it ideal for use in Western blot applications. It binds specifically to the FBXW4 protein, allowing for detection and analysis in various cell types.FBXW4 plays a crucial role in the ubiquitin-proteasome system, targeting specific proteins for degradation and thereby regulating various cellular processes. Dysregulation of FBXW4 has been implicated in diseases such as cancer and neurodegenerative disorders, making it a valuable target for research in these areas.
Understanding the function of FBXW4 can provide insights into disease mechanisms and potential therapeutic interventions.Overall, the FBXW4 Polyclonal Antibody (CAB8149) is a valuable tool for researchers studying FBXW4 and its role in cellular processes and disease pathogenesis. Its high reactivity and specificity make it a reliable reagent for investigations in molecular biology, cancer research, and drug development.
Product Name:
FBXW4 Rabbit Polyclonal Antibody
SKU:
CAB8149
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 143-412 of human FBXW4 (NP_071322.1).
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
Purification Method:
Affinity purification
Gene ID:
6468
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse brain, using FBXW4 antibody (CAB8149) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
