The FBXO28 Polyclonal Antibody (CAB17659) is a valuable tool for researchers studying the FBXO28 protein, a key player in the regulation of cellular processes such as protein degradation and cell cycle progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the FBXO28 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential asset for investigations in cell biology and cancer research.
FBXO28 is a crucial component of the ubiquitin-proteasome system, which helps to maintain cellular homeostasis by targeting proteins for degradation. Dysregulation of FBXO28 has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in cellular function and disease progression. By elucidating the role of FBXO28 in these pathologies, researchers can uncover potential therapeutic targets for the development of novel treatments.
Product Name:
FBXO28 Rabbit Polyclonal Antibody
SKU:
CAB17659
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 91-312 of human FBXO28 (NP_055991.1).
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Purification Method:
Affinity purification
Gene ID:
23219
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FBXO28 Rabbit pAb (CAB17659) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
