The Fas Polyclonal Antibody (CAB2639) is a vital tool for researchers studying the Fas protein, a cell surface receptor involved in apoptosis and immune regulation. This antibody is raised in rabbits and has high reactivity with human samples, making it an ideal choice for Western blot applications. Fas, also known as CD95, is a crucial component of the extrinsic apoptotic pathway and is involved in regulating immune responses. The Fas Polyclonal Antibody binds specifically to the Fas protein, allowing for accurate detection and analysis in various cell types.
This makes it invaluable for studies in immunology, cancer research, and other fields where apoptosis and immune regulation are of interest.Understanding the function and regulation of Fas is essential for developing targeted therapies for diseases such as cancer, autoimmune disorders, and inflammatory conditions. By utilizing the Fas Polyclonal Antibody in research, scientists can gain valuable insights into the role of Fas in these diseases and potentially uncover new treatment strategies.
Product Name:
Fas Rabbit Polyclonal Antibody
SKU:
CAB2639
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Fas (NP_000034.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
38kDa
Observed MW:
40-50kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Purification Method:
Affinity purification
Gene ID:
355
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Fas Rabbit pAb (CAB2639) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
