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FAS Monoclonal Antibody [NYRhFAS] (CPAB0044)

SKU:
CPAB0044
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
NYRhFAS
€660
Frequently bought together:

Description

system_update_alt Datasheet

FAS Monoclonal Antibody [NYRhFAS] (CPAB0044)

The Fas Polyclonal Antibody (CPAB0044) is a valuable tool for researchers studying the Fas protein, which is involved in apoptosis (cell death) and immune regulation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Fas protein, this antibody allows for the detection and analysis of Fas expression in a variety of cell types, making it suitable for use in studies related to immunology, cancer biology, and other research fields.Fas, also known as CD95 or APO-1, plays a crucial role in regulating cell death and immune responses.

Dysregulation of the Fas signaling pathway has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Therefore, investigating the function and expression of Fas is important for understanding these disease processes and for developing targeted therapies.Overall, the Fas Polyclonal Antibody (CPAB0044) is an essential tool for researchers interested in studying the role of Fas in health and disease. Its high specificity, reactivity, and validation make it a reliable reagent for a wide range of applications in the field of biomedical research.

Product Name:FAS Antibody
Product Sku:CPAB0044
Size:500μg
Host Species:mouse
Immunogen:Recombinant Human FAS.
Clone:NYRhFAS.
Reactivity:Human
Applications:
Purification Method:Protein-A column.
Isotype:IgG1
Background:The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligimerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated, to then cleave and activate downstream caspases, and a variety of cellular substrates that lead to cell death. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of fas-mediated apoptosis using similar mechanisms.
Synonyms:FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95, Tumor necrosis factor receptor superfamily member 6 TNR6, APT1, FAS1, TNFRSF6.
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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