The FAR1 Polyclonal Antibody (CAB16284) is a valuable tool for researchers studying the FAR1 protein, a key player in cellular responses to stress and DNA damage. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the FAR1 protein, researchers can easily detect and analyze its presence in various cell types, facilitating studies in areas such as DNA repair, apoptosis, and cell cycle regulation.FAR1, also known as Fas associated factor 1, is involved in mediating cell death and survival pathways in response to external stressors, making it a crucial target for investigation in cancer research and drug development.
Its role in regulating cell growth and DNA repair processes underscores its importance in maintaining genomic stability and preventing the development of cancerous cells. Research into the function of FAR1 is essential for advancing our understanding of cancer biology and identifying novel therapeutic strategies for combating the disease.
Product Name:
FAR1 Rabbit Polyclonal Antibody
SKU:
CAB16284
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FAR1 (NP_115604.1).
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13.
Purification Method:
Affinity purification
Gene ID:
84188
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FAR1 Rabbit pAb (CAB16284) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
