The FANCF Antibody (PAC016308) is a valuable tool for research involving the FANCF protein, a key component of the Fanconi Anemia pathway which is essential for DNA repair and maintenance of genomic stability. This polyclonal antibody, produced in rabbits, is highly specific for FANCF and has been validated for use in a variety of applications including Western blot and immunohistochemistry.FANCF plays a critical role in maintaining genomic integrity by facilitating the repair of interstrand DNA crosslinks and protecting cells from DNA damage. Mutations in FANCF are associated with Fanconi Anemia, a rare genetic disorder characterized by bone marrow failure and increased cancer susceptibility.
By targeting FANCF, researchers can gain insight into the molecular mechanisms underlying these diseases and potentially develop novel therapeutic interventions.Whether investigating the role of FANCF in DNA repair pathways, studying the effects of FANCF mutations on cellular function, or exploring potential targeted therapies for Fanconi Anemia and associated cancers, the FANCF Antibody is an essential tool for researchers in the fields of genetics, oncology, and molecular biology.
Antibody Name:
FANCF Antibody (PACO16308)
Antibody SKU:
PACO16308
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Fusion protein of human FANCF
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16308(FANCF Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16308(FANCF Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F.
Synonyms:
Fanconi anemia, complementation group F
UniProt Protein Function:
FANCF: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCF are the cause of Fanconi anemia complementation group F (FANCF). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 11p14.3Cellular Component: nucleoplasmMolecular Function: protein bindingDisease: Fanconi Anemia, Complementation Group F; Tracheoesophageal Fistula With Or Without Esophageal Atresia
UniProt Protein Details:
NCBI Summary:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]
