The FANCC Polyclonal Antibody (CAB1812) is a valuable tool for researchers studying FANCC, a protein involved in DNA repair pathways and maintenance of genomic stability. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the FANCC protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in genetics, molecular biology, and cancer research.FANCC is a key player in the Fanconi anemia pathway, a crucial DNA repair mechanism that safeguards cells against DNA damage and mutations. Dysregulation of FANCC has been implicated in various genetic disorders and cancers, highlighting its importance in maintaining genetic integrity.
By elucidating the function and regulation of FANCC, researchers can gain insights into the underlying mechanisms of disease development and potentially identify new therapeutic targets for precision medicine approaches.Overall, the FANCC Polyclonal Antibody (CAB1812) serves as a valuable tool for investigating the role of FANCC in DNA repair processes and its impact on human health. Its high specificity and sensitivity make it a reliable choice for scientists looking to advance their understanding of genomic stability and disease mechanisms.
Product Name:
FANCC Rabbit Polyclonal Antibody
SKU:
CAB1812
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 340-558 of human FANCC (NP_000127.2).
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.
Purification Method:
Affinity purification
Gene ID:
2176
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FANCC Rabbit pAb (CAB1812) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
