The FAN1 Polyclonal Antibody (PAC010646) is a valuable tool for researchers studying FAN1, a protein involved in DNA repair mechanisms. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it an excellent choice for Western blot applications. By binding to the FAN1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential reagent for studies in genetics and cancer biology.FAN1 is a critical player in DNA damage repair pathways, particularly in the resolution of DNA interstrand crosslinks. Dysregulation of FAN1 function has been linked to various diseases, including cancer and genetic disorders.
By studying the role of FAN1 in DNA repair processes, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the FAN1 Polyclonal Antibody is a valuable resource for researchers interested in investigating the functions and implications of FAN1 in DNA repair and disease development. Its high specificity and reliability make it a trusted tool for advancing our understanding of genetic maintenance and potential therapeutic strategies.
myotubularin related protein 15;MTMR15;DKFZp451H236;DKFZp686K16147;KIAA1018 ;
UniProt Protein Function:
FAN1: Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap- specific enzymes to unhook the ICL by cleaving the lagging-strand template. Belongs to the FAN1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.4.1; Deoxyribonuclease; Ubiquitin conjugating system; DNA repair, damageChromosomal Location of Human Ortholog: 15q13.2-q13.3Cellular Component: cytoplasm; intercellular bridge; nucleoplasm; nucleusMolecular Function: 5'-3' exonuclease activity; 5'-flap endonuclease activity; magnesium ion binding; protein binding; ubiquitin bindingBiological Process: DNA repair; double-strand break repair via homologous recombination; nucleotide-excision repair; nucleotide-excision repair, DNA incisionDisease: Interstitial Nephritis, Karyomegalic
UniProt Protein Details:
NCBI Summary:
This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016]
