The FAM89B Polyclonal Antibody (PAC016306) is a crucial tool for researchers studying FAM89B, a protein involved in cellular processes such as cell cycle progression and DNA repair. This antibody, produced using rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By binding to the FAM89B protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.FAM89B, also known as a key regulator of cell division, plays a vital role in maintaining genomic stability and ensuring proper cell growth and proliferation.
Its involvement in these critical processes makes it a promising target for investigation in diseases such as cancer, where aberrant cell division and DNA repair mechanisms contribute to tumorigenesis. By studying the function of FAM89B, researchers can gain valuable insights into the molecular mechanisms underlying cancer development and identify potential targets for therapeutic intervention.
Antibody Name:
FAM89B Antibody (PACO16306)
Antibody SKU:
PACO16306
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human FAM89B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16306(FAM89B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Mtvr1 (mammary tumor virus receptor homolog 1), also known as FAM89B (family with sequence similarity 89, member B), is a 176 amino acid, protein that exists as two alternatively spliced isoforms. Belonging to the FAM89 family, Mtvr1 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
Synonyms:
family with sequence similarity 89, member B
UniProt Protein Function:
FAM89B: Belongs to the FAM89 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.Chromosomal Location of Human Ortholog: 11q13Cellular Component: cell surface; cytoplasmBiological Process: negative regulation of transforming growth factor beta receptor signaling pathway
