The EXTL1 Polyclonal Antibody (PACO19638) is a valuable tool for researchers studying the role of EXTL1 in various cellular processes. EXTL1 is a gene that encodes for a glycosyltransferase enzyme involved in the biosynthesis of heparan sulfate and heparin. This antibody, generated in rabbits, is highly specific for human EXTL1 and has been validated for use in Western blot applications.EXTL1 plays a crucial role in the regulation of cell growth, differentiation, and migration, making it a key player in processes such as development, wound healing, and cancer progression.
By targeting EXTL1 with this antibody, researchers can investigate its function in different cell types and gain insights into its potential as a therapeutic target in diseases such as cancer and genetic disorders.With its high reactivity and specificity, the EXTL1 Polyclonal Antibody is a valuable tool for researchers looking to unravel the complexities of EXTL1-mediated pathways and their implications in various physiological and pathological conditions.
Antibody Name:
EXTL1 Antibody (PACO19638)
Antibody SKU:
PACO19638
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human EXTL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19638(EXTL1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors α 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.
Synonyms:
exostosin-like glycosyltransferase 1
UniProt Protein Function:
EXTL1: Probable glycosyltransferase. Belongs to the glycosyltransferase 47 family.Protein type: Membrane protein, integral; Transferase; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.224Chromosomal Location of Human Ortholog: 1p36.1Biological Process: skeletal development
UniProt Protein Details:
NCBI Summary:
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008]
