The ESX1 Polyclonal Antibody (PACO09149) is a powerful tool for researchers studying ESX1, a protein involved in immune response regulation and immune cell function. This high-quality antibody, produced in rabbits, demonstrates strong reactivity with human samples and is validated for use in Western blot applications.ESX1 is known to play a significant role in the immune system, specifically in inflammation and immune cell activation. By binding to the ESX1 protein, this antibody enables researchers to detect and analyze ESX1 expression in various cell types, making it an excellent tool for studies in immunology and cancer research.
With ESX1 being implicated in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions, understanding its function is crucial for developing targeted therapies that modulate immune responses. The ESX1 Polyclonal Antibody provides researchers with a reliable means to investigate the role of ESX1 in these diseases and potentially discover new treatment options.
ESX1L: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.Protein type: DNA-bindingChromosomal Location of Human Ortholog: Xq22.1Cellular Component: cytoplasm; nucleusMolecular Function: sequence-specific DNA bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of cell cycle
UniProt Protein Details:
NCBI Summary:
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]
