The ERCC5 Polyclonal Antibody (CAB1605) is a valuable tool for researchers studying ERCC5, a protein involved in DNA repair mechanisms. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ERCC5 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.ERCC5, also known as xeroderma pigmentosum group G protein, is a crucial component of the nucleotide excision repair pathway, which repairs DNA damage caused by ultraviolet (UV) light and other mutagens.
Mutations in ERCC5 are associated with several genetic disorders, including xeroderma pigmentosum and Cockayne syndrome. Understanding the role of ERCC5 in DNA repair processes is essential for elucidating its implications in disease development and progression.With its high specificity and sensitivity, the ERCC5 Polyclonal Antibody (CAB1605) is a valuable resource for researchers investigating the molecular mechanisms underlying DNA repair and genomic stability. By facilitating the study of ERCC5 expression and function, this antibody contributes to the advancement of knowledge in the fields of genetics, cancer biology, and beyond.
Product Name:
ERCC5 Rabbit Polyclonal Antibody
SKU:
CAB1605
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ERCC5 (NP_000114.2).
This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
Purification Method:
Affinity purification
Gene ID:
2073
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of C6 cells using ERCC5 Polyclonal Antibody (CAB1605) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
