ERCC5 Rabbit Polyclonal Antibody (CAB1605)
- SKU:
- CAB1605
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ERCC5 Rabbit Polyclonal Antibody |
SKU: | CAB1605 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ERCC5 (NP_000114.2). |
Sequence: | MGVQ GLWK LLEC SGRQ VSPE ALEG KILA VDIS IWLN QALK GVRD RHGN SIEN PHLL TLFH RLCK LLFF RIRP IFVF DGDA PLLK KQTL VKRR QRKD LASS DSRK TTEK LLKT FLKR QAIK TAFR SKRD EALP SLTQ VRRE NDLY VLPP LQEE EKHS SEEE DEKE WQER MNQK QALQ EEFF HNPQ AIDI ESED FSSL PPEV KHEI LTDM KEFT KRRR TLFE AMPE ESDD FSQY QLKG LLKK NYLN QHIE HVQK EMNQ QHSG HIRR QYED EG |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | XPG; UVDR; XPGC; COFS3; ERCM2; ERCC5-201; ERCC5 |
Positive Sample: | fetal brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 133kDa |
Observed MW: | Refer to figures |
This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
Purification Method: | Affinity purification |
Gene ID: | 2073 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |