The ERAS Antibody (PAC019613) is a polyclonal antibody designed for research involving ERAS, a cell surface molecule that plays a crucial role in regulating cell proliferation and survival. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It specifically binds to the ERAS protein, allowing for precise detection and analysis in various cell types.ERAS, also known as Embryonic stem cell-expressed Ras, is an important regulator of cell growth and differentiation. Its involvement in key cellular processes makes it a promising target for studying various diseases, including cancer and developmental disorders.
By understanding the function of ERAS, researchers can gain insights into how abnormal cell signaling contributes to pathological conditions and potentially identify new therapeutic strategies.The ERAS Antibody is a valuable tool for researchers studying cell signaling pathways, cancer biology, and developmental biology. Its ability to selectively detect ERAS protein levels in different experimental settings makes it an essential component for experiments aimed at uncovering the role of ERAS in health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19613(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO19613(ERAS Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19613(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance.
Synonyms:
ES cell expressed Ras
UniProt Protein Function:
ERas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells. Belongs to the small GTPase superfamily. Ras family.Protein type: G protein, monomeric, Ras; G protein, monomeric; G proteinChromosomal Location of Human Ortholog: Xp11.23
UniProt Protein Details:
NCBI Summary:
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
