The EPS8L1 Polyclonal Antibody (PAC023270) is a valuable tool for researchers studying EPS8L1, a protein involved in cell signaling and cytoskeletal dynamics. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to EPS8L1, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it well-suited for investigations in molecular biology and cancer research.
EPS8L1, a member of the EPS8 family, plays a crucial role in regulating actin dynamics and cell migration, and its dysregulation has been linked to cancer progression and metastasis. By studying the function and expression of EPS8L1, researchers can gain valuable insights into tumorigenesis and potential therapeutic targets for cancer treatment. This antibody is a valuable tool for exploring the biology of EPS8L1 and its implications in disease progression.
Synthesized peptide derived from internal of human ES8L1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO205 cells, using ES8L1 antibody.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ES8L1 antibody.
Background:
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
Synonyms:
Epidermal growth factor receptor kinase substrate 8-like protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-like protein 1; EPS8L1; DRC3
UniProt Protein Function:
EPS8L1: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: cytoplasm; protein complex
Molecular Function:actin binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; T cell receptor binding
Biological Process: regulation of Rho protein signal transduction; Rho protein signal transduction
NCBI Summary:
This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
