The EPN3 Polyclonal Antibody (PAC053178) is a specialized tool for researchers investigating EPN3, a key player in endocytosis and membrane trafficking processes. This antibody, produced through the immunization of rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications. By binding specifically to the EPN3 protein, this antibody enables the accurate detection and analysis of EPN3 in various cell types, making it an invaluable asset for studies in cell biology and molecular biology.EPN3, also known as Epsin family protein 3, plays a crucial role in regulating the internalization of cell surface receptors and the trafficking of endocytic vesicles within cells.
Its involvement in these fundamental processes highlights its importance in understanding normal cellular function and its dysregulation in diseases such as cancer and neurodegenerative disorders. By investigating the function of EPN3, researchers can gain insights into potential therapeutic targets for these conditions and enhance our understanding of cellular dynamics.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO53178 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO53178 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO53178 at dilution of 1:100.
Background:
clathrin-coated vesicle, extracellular exosome, extrinsic component of plasma membrane, intracellular membrane-bounded organelle, nucleoplasm, nucleus, perinuclear region of cytoplasm
Synonyms:
Epsin-3 (EPS-15-interacting protein 3), EPN3
UniProt Protein Function:
epsin 3: Belongs to the epsin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: VesicleChromosomal Location of Human Ortholog: 17q21.33Cellular Component: clathrin-coated vesicle; extrinsic to plasma membrane; intracellular membrane-bound organelle; nucleoplasm; nucleus; perinuclear region of cytoplasmMolecular Function: protein binding
