The EphA2 Polyclonal Antibody (CAB7183) is a valuable tool for researchers studying EphA2, a receptor tyrosine kinase involved in various cellular processes, including cell adhesion, migration, and proliferation. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blotting and immunohistochemistry applications.EphA2 plays a critical role in cancer progression and metastasis, making it a promising target for cancer research. By using the EphA2 Polyclonal Antibody, researchers can detect and analyze EphA2 expression in different cell types, providing insights into its function in cancer biology.
Additionally, understanding the signaling pathways mediated by EphA2 can lead to the development of targeted therapies for cancer treatment.Overall, the EphA2 Polyclonal Antibody is a reliable tool for studying EphA2 biology and its implications in cancer research. Its high specificity and sensitivity make it a valuable asset for researchers aiming to unravel the complex role of EphA2 in cancer development and progression.
Product Name:
EPHA2 Rabbit Polyclonal Antibody
SKU:
CAB7183
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 280-530 of human EPHA2 (NP_004422.2).
Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, focal adhesion, lamellipodium membrane, ruffle membrane.
Calculated MW:
108kDa
Observed MW:
125kDa
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Purification Method:
Affinity purification
Gene ID:
1969
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EPHA2 antibody (CAB7183) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
