Description
Product Name: | EP300 Polyclonal Antibody |
SKU: | CAB24352 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 940-1030 of human EP300(NP_001420.2). |
Sequence: | LSQP AVSI EGQV SNPP STSS TEVN SQAI AEKQ PSQE VKME AKME VDQP EPAD TQPE DISE SKVE DCKM ESTE TEER STEL KTEI KEEE DQP |
Tested Applications: | IHC-P ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 |
Synonyms: | p300; KAT3B; MKHK2; RSTS2; EP300 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 264kDa |
Observed MW: | Refer to figures |
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Purification Method: | Affinity purification |
Gene ID: | 2033 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |