The Engrailed-1 Polyclonal Antibody is a valuable research tool for scientists studying the Engrailed-1 protein, which plays a crucial role in embryonic development and neurogenesis. This antibody, produced in rabbits, is highly specific to Engrailed-1 and has been validated for use in various applications, including Western blot and immunohistochemistry. It enables researchers to detect and analyze Engrailed-1 expression in cells and tissues, providing important insights into its function in development and disease.Engrailed-1 is known to be essential for the formation of the midbrain and cerebellum, as well as for the patterning of neuronal circuits in the central nervous system.
Dysregulation of Engrailed-1 expression has been linked to neurological disorders such as Parkinson's disease and autism spectrum disorders, making it a promising target for therapeutic interventions. By studying the role of Engrailed-1 using this antibody, researchers can advance our understanding of brain development and potentially uncover new treatment strategies for these conditions.
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
Purification Method:
Affinity purification
Gene ID:
2019
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of A-431 cells using Engrailed 1 Rabbit pAb (CAB23060) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
