Anti-ELMOD2 Antibody (CAB14524)
- SKU:
- CAB14524
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Anti-ELMOD2 Antibody (CAB14524)
The ELMO Domain Containing 2 (ELMOD2) Polyclonal Antibody (CAB14524) is a valuable tool for researchers studying ELMOD2, a protein involved in intracellular trafficking and membrane dynamics. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications.ELMOD2 plays a crucial role in regulating various cellular processes, including vesicle trafficking and membrane fusion events. Its involvement in these pathways suggests potential implications in cell signaling, organelle biogenesis, and cellular homeostasis. By targeting ELMOD2 with this antibody, researchers can explore its functional roles in different cell types and gain insights into its physiological significance.
Studies have linked ELMOD2 to diseases such as neurodegenerative disorders, cancer, and metabolic syndromes, highlighting its potential as a therapeutic target. Investigating the molecular mechanisms underlying ELMOD2 function can provide valuable information for developing novel treatment strategies aimed at modulating intracellular pathways affected by this protein. Overall, the ELMOD2 Polyclonal Antibody is a valuable research tool for unraveling the complex functions of ELMOD2 in various biological processes.
| Antibody Name: | Anti-ELMOD2 Antibody |
| Antibody SKU: | CAB14524 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 5-95 of human ELMOD2 (NP_714913.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 5-95 of human ELMOD2 (NP_714913.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LWEF FYGH FFRF WMKW LLRQ MTGK CELQ RIFD TYVG AQRT HRIE NSLT YSKN KVLQ KATH VVQS EVDK YVDD IMKE KNIN PEKD ASFK ICM |
| Gene ID: | 255520 |
| Uniprot: | Q8IZ81 |
| Cellular Location: | |
| Calculated MW: | 34kDa |
| Observed MW: | 33kDa |
| Synonyms: | ELMOD2, 9830169G11Rik |
| Background: | This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. |
| UniProt Protein Function: | ELMOD2: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q31.1 Cellular Component: membrane Molecular Function:GTPase activator activity Biological Process: regulation of defense response to virus Disease: Pulmonary Fibrosis, Idiopathic |
| NCBI Summary: | This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q8IZ81 |
| NCBI GenInfo Identifier: | 74728441 |
| NCBI Gene ID: | 255520 |
| NCBI Accession: | Q8IZ81.1 |
| UniProt Secondary Accession: | Q8IZ81,B2R712, D3DNZ0, |
| UniProt Related Accession: | Q8IZ81 |
| Molecular Weight: | 34,961 Da |
| NCBI Full Name: | ELMO domain-containing protein 2 |
| NCBI Synonym Full Names: | ELMO domain containing 2 |
| NCBI Official Symbol: | ELMOD2Â Â |
| NCBI Official Synonym Symbols: | 9830169G11Rik  |
| NCBI Protein Information: | ELMO domain-containing protein 2 |
| UniProt Protein Name: | ELMO domain-containing protein 2 |
| Protein Family: | ELMO domain-containing protein |
| UniProt Gene Name: | ELMOD2Â Â |
| UniProt Entry Name: | ELMD2_HUMAN |
 | Western blot analysis of extracts of rat lung, using ELMOD2 antibody (CAB14524) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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