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EFNA2 Antibody (PACO21689)

SKU:
PACO21689
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$503
Frequently bought together:

Description

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EFNA2 Antibody (PACO21689)

The EFNA2 Polyclonal Antibody (PAC021689) is a crucial tool for researchers studying the Ephrin-A2 receptor, a key player in cell communication and signaling processes. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an excellent choice for experiments involving Western blot applications. By binding to the EFNA2 protein, this antibody enables precise detection and analysis in diverse cell types, facilitating investigations in the fields of neuroscience, developmental biology, and cancer research.The Ephrin-A2 receptor is known for its involvement in axon guidance, synaptic plasticity, and tumor progression, highlighting its importance in various physiological and pathological processes.

Research on EFNA2 is essential for unraveling its intricate roles in neural development, synaptic transmission, and cancer metastasis, offering insights into potential therapeutic strategies targeting these mechanisms. By elucidating the functions of EFNA2, scientists can advance their understanding of complex biological processes and develop innovative treatments for neurological disorders and cancer.

Antibody Name:EFNA2 Antibody (PACO21689)
Antibody SKU:PACO21689
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from Internal of human EFNA2.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from COLO205 cells and HeLa cells, using EFNA2 antibody.
Background:Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis By similarity. Aasheim H.C., Biochem. Biophys. Res. Commun. 252:378-382(1998).
Synonyms:Ephrin-A2 [Precursor]; EPH-related receptor tyrosine kinase ligand 6; LERK-6; HEK7-ligand; HEK7-L
UniProt Protein Function:EFNA2: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Belongs to the ephrin family.Protein type: Membrane protein, GPI anchor; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 19p13.3Cellular Component: extracellular region; plasma membrane; perikaryon; neuromuscular junctionMolecular Function: ephrin receptor bindingBiological Process: axon guidance; cell-cell signaling; olfactory bulb development; ephrin receptor signaling pathway; osteoclast differentiation; bone remodeling
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
UniProt Code:O43921
NCBI GenInfo Identifier:27894381
NCBI Gene ID:1943
NCBI Accession:NP_001396.2
UniProt Secondary Accession:O43921
UniProt Related Accession:O43921
Molecular Weight:~ 24kDa
NCBI Full Name:ephrin-A2
NCBI Synonym Full Names:ephrin A2
NCBI Official Symbol:EFNA2  
NCBI Official Synonym Symbols:ELF-1; EPLG6; LERK6; HEK7-L; LERK-6  
NCBI Protein Information:ephrin-A2
UniProt Protein Name:Ephrin-A2
UniProt Synonym Protein Names:EPH-related receptor tyrosine kinase ligand 6; LERK-6; HEK7 ligand
Protein Family:Ephrin
UniProt Gene Name:EFNA2  
UniProt Entry Name:EFNA2_HUMAN
AntibodiesELISA Kits
Cleaved-EFNA2 (N188) Antibody (PACO00028)Human Ephrin-A2 (EFNA2) ELISA Kit
EFNA2 Antibody (PACO00766)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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