The E2 Antibody (PACO34854) is a high-quality monoclonal antibody designed for research involving E2, a key protein involved in viral replication and infection, specifically targeting the E2 protein of interest. This antibody is produced in a state-of-the-art facility using cutting-edge technology, ensuring high specificity and sensitivity in detecting E2 in various samples. It has been rigorously validated for use in applications such as immunofluorescence, immunohistochemistry, and flow cytometry, making it a versatile tool for studying E2-related processes in virology and infectious disease research.
The E2 protein plays a crucial role in the lifecycle of certain viruses, making it a valuable target for investigating viral pathogenesis and developing antiviral strategies. By using the E2 Antibody (PACO34854), researchers can gain valuable insights into the function and localization of the E2 protein, helping to advance our understanding of viral infections and potentially leading to the development of novel therapeutics.
Antibody Name:
E2 Antibody (PACO34854)
Antibody SKU:
PACO34854
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human papillomavirus type 18
Immunogen:
Recombinant Human papillomavirus type 18 Regulatory protein E2 protein (1-365AA)
E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
Synonyms:
Regulatory protein E2, E2
UniProt Protein Function:
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
