The Dynactin Subunit 1 Polyclonal Antibody (CAB1783) is a vital tool for researchers studying the role of dynactin subunit 1 in cellular functions and processes. Dynactin subunit 1 is a key component of the dynactin complex, essential for intracellular transport and organization of cellular structures.This antibody, generated in rabbits, shows high specificity and reactivity towards human samples, making it an excellent choice for Western blot applications. By targeting dynactin subunit 1, researchers can analyze its expression and function in various cell types, providing insights into its involvement in cellular trafficking, mitosis, and cell division.
Dynactin subunit 1 is a crucial player in maintaining cellular homeostasis and overall cell health. Dysregulation of its function has been linked to various diseases, including neurodegenerative disorders and cancer. Research utilizing this antibody can uncover new therapeutic targets and pathways for the treatment of these conditions.By using the Dynactin Subunit 1 Polyclonal Antibody (CAB1783), researchers can deepen their understanding of the role of dynactin subunit 1 in cellular processes, paving the way for innovative discoveries in cell biology and disease mechanisms.
Product Name:
DCTN1 Rabbit Polyclonal Antibody
SKU:
CAB1783
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 945-1139 of human DCTN1 (NP_001128513.1).
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
Purification Method:
Affinity purification
Gene ID:
1639
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using DCTN1 Rabbit pAb (CAB1783) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
