The DUSP11 Polyclonal Antibody (PACO08952) is a valuable tool for researchers studying the DUSP11 protein, a member of the dual-specificity phosphatase (DUSP) family involved in the regulation of mitogen-activated protein kinase (MAPK) signaling pathways. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.DUSP11 plays a crucial role in the fine-tuning of MAPK signaling, which is essential for cell growth, differentiation, and stress responses. Dysregulation of MAPK signaling has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
By targeting DUSP11, researchers can gain insights into the mechanisms underlying these diseases and explore potential therapeutic interventions.With its specificity and sensitivity, the DUSP11 Polyclonal Antibody is a valuable tool for investigating the functions and regulatory mechanisms of DUSP11 in different cell types and disease contexts. Its application in research areas such as cancer biology, neurobiology, and immunology makes it a versatile and essential reagent for scientists seeking to uncover new insights into cellular signaling pathways and disease mechanisms.
DUSP11: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.-; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 2p13.1Cellular Component: nuclear speck; nucleusMolecular Function: phosphoric monoester hydrolase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; RNA bindingBiological Process: protein amino acid dephosphorylation; RNA metabolic process; RNA processing
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
