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DUS2 Antibody (PACO23287)

SKU:
PACO23287
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • DUS2 Antibody PACO23287
  • DUS2 Antibody PACO23287
€419
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Description

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DUS2 Antibody (PACO23287)

The DUS2 Polyclonal Antibody (PAC023287) is a valuable tool for researchers studying DUS2, a protein involved in RNA processing and mRNA stability. This antibody, produced in rabbits, shows high specificity for human samples and has been validated for use in Western blotting applications. By binding to the DUS2 protein, this antibody allows for the detection and analysis of DUS2 in a variety of cell types, making it an ideal choice for studies in molecular biology and gene regulation.DUS2, also known as dihydrouridine synthase 2, plays a crucial role in maintaining RNA integrity and stability, making it a key player in post-transcriptional gene expression regulation.

Dysregulation of DUS2 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting the importance of understanding its function. By investigating the role of DUS2 in different cellular processes, researchers can gain insights into potential therapeutic targets for these conditions.

Antibody Name:DUS2 Antibody (PACO23287)
Antibody SKU:PACO23287
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from C-terminal of human DUS2L.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from RAW264.7 cells, using DUS2L antibody.
Product ImageImmunohistochemistry analysis of paraffin-embedded human skeletal muscle using DUS2L antibody.
Background:Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.
Synonyms:tRNA-dihydrouridine synthase 2-like; EC 1.-.-.-; hDUS2; Up-regulated in lung cancer; URLC8
UniProt Protein Function:DUS2L: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Belongs to the dus family. Dus2 subfamily.Protein type: EC 1.3.1.-; EC 1.-.-.-; RNA-binding; OxidoreductaseChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; cytosolMolecular Function: double-stranded RNA binding; protein binding; protein kinase inhibitor activity; tRNA dihydrouridine synthase activity
UniProt Protein Details:
NCBI Summary:This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
UniProt Code:Q9NX74
NCBI GenInfo Identifier:73620832
NCBI Gene ID:54920
NCBI Accession:Q9NX74.1
UniProt Secondary Accession:Q9NX74,Q4H4D9, A8K3G3
UniProt Related Accession:Q9NX74
Molecular Weight:55,050 Da
NCBI Full Name:tRNA-dihydrouridine(20) synthase
NCBI Synonym Full Names:dihydrouridine synthase 2
NCBI Official Symbol:DUS2  
NCBI Official Synonym Symbols:SMM1; DUS2L; URLC8  
NCBI Protein Information:tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
UniProt Protein Name:tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
UniProt Synonym Protein Names:Dihydrouridine synthase 2; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2
Protein Family:Probable tRNA-dihydrouridine synthase
UniProt Gene Name:DUS2  
UniProt Entry Name:DUS2L_HUMAN
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