The DRAM2 Polyclonal Antibody (PAC044804) is a versatile tool for researchers studying the DRAM2 protein, a key regulator of autophagy and cellular homeostasis. This antibody, produced using rabbits as the host species, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the DRAM2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an invaluable asset for research in the fields of cell biology and cancer.DRAM2, also known as damage-regulated autophagy modulator 2, is a vital player in the autophagy pathway, responsible for clearing damaged organelles and proteins to maintain cellular health.
Dysregulation of DRAM2 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. By studying the role of DRAM2 in these contexts, researchers can gain valuable insights into disease mechanisms and potentially develop new therapeutic strategies targeting autophagy pathways.Overall, the DRAM2 Polyclonal Antibody offers researchers a reliable tool for studying the function and regulation of DRAM2 in various cellular processes, paving the way for advancements in understanding disease pathogenesis and identifying potential therapeutic targets.
Recombinant Human DNA damage-regulated autophagy modulator protein 2 protein (182-266AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot. All lanes: DRAM2 antibody at 3.84µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 30 kDa. Observed band size: 30 kDa..
Immunohistochemistry of paraffin-embedded human heart tissue using PACO44804 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human bladder cancer using PACO44804 at dilution of 1:100.
Background:
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
Synonyms:
DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77), DRAM2, TMEM77
UniProt Protein Function:
TMEM77: Induces apoptotic cell death when coexpressed with DRAM1. Belongs to the DRAM/TMEM150 family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1p13.3Cellular Component: apical plasma membrane; cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; lysosome; photoreceptor inner segmentBiological Process: photoreceptor cell maintenance; regulation of autophagy; visual perceptionDisease: Cone-rod Dystrophy 21
