The Dock6 Antibody (PAC046942) is a valuable tool for researchers studying the Dock6 protein, a key player in cell signaling pathways and immune responses. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.Dock6 is known for its role in regulating cellular processes such as cell migration and proliferation, making it a potential target for studies in immunology, cancer research, and beyond. By specifically binding to the Dock6 protein, this antibody enables accurate detection and analysis in various cell types, providing valuable insights into the function and regulation of Dock6.
Understanding the mechanisms underlying Dock6 activity is essential for unraveling its potential role in diseases like cancer, autoimmune disorders, and inflammatory conditions. By utilizing the Dock6 Antibody, researchers can further advance their understanding of the complex interplay between Dock6 and immune responses, paving the way for targeted therapies and interventions in the future.
Antibody Name:
DOCK6 Antibody (PACO46942)
Antibody SKU:
PACO46942
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Dedicator of cytokinesis protein 6 protein (499-616AA)
Immunohistochemistry of paraffin-embedded human brain tissue using PACO46942 at dilution of 1:100.
Background:
Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).
Synonyms:
Dedicator of cytokinesis protein 6, DOCK6, KIAA1395
UniProt Protein Function:
DOCK6: Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth. Defects in DOCK6 are the cause of Adams-Oliver syndrome type 2 (AOS2). A disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. Belongs to the DOCK family.Protein type: GEFs, misc.; Motility/polarity/chemotaxis; GEFsChromosomal Location of Human Ortholog: 19p13.2Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosolMolecular Function: guanyl-nucleotide exchange factor activityBiological Process: small GTPase mediated signal transduction; blood coagulation; positive regulation of GTPase activityDisease: Adams-oliver Syndrome 2
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
