The DNTTIP1 Polyclonal Antibody (CAB15558) is a vital tool for researchers studying DNTTIP1, a protein involved in DNA repair and maintenance. This antibody, generated in rabbits, demonstrates high specificity for human samples and is validated for use in applications such as Western blotting.DNTTIP1, also known as DNA polymerase zeta, plays a crucial role in the error-prone translesion synthesis pathway, allowing for the bypass of DNA lesions during replication. Its function in DNA repair processes makes it a key target for investigations in cancer biology and genotoxic stress responses.
With this antibody, researchers can accurately detect and analyze DNTTIP1 expression in various cell types, aiding in the understanding of its role in DNA damage repair mechanisms.By studying DNTTIP1, researchers can gain valuable insights into the molecular mechanisms underlying DNA damage response pathways and potential targets for cancer therapy. The DNTTIP1 Polyclonal Antibody is an essential tool for advancing research in genomics, oncology, and beyond.
Product Name:
DNTTIP1 Rabbit Polyclonal Antibody
SKU:
CAB15558
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human DNTTIP1 (NP_443183.1).
DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).
Purification Method:
Affinity purification
Gene ID:
116092
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNTTIP1 Rabbit pAb (CAB15558) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5S.
