The DNAaf5 Polyclonal Antibody (PACO37374) is a key tool for researchers studying DNAaf5, a protein involved in DNA replication and repair processes. This antibody, produced through rabbit immunization, demonstrates high reactivity with human samples and is validated for use in Western blotting applications. By binding specifically to the DNAaf5 protein, researchers can accurately detect and analyze this crucial component in various cell types, making it an essential tool for studies in genetics and molecular biology.DNAaf5, also known as DNA replication factor Cdt1, plays a vital role in ensuring the fidelity of DNA replication and maintenance of genome stability.
Understanding the functions and regulation of DNAaf5 is essential for unraveling the mechanisms underlying genetic disorders, cancer development, and aging-related diseases. With its ability to target DNAaf5, this antibody enables researchers to explore the intricate pathways involved in DNA replication and repair, paving the way for potential therapeutic interventions in a wide range of diseases.
Antibody Name:
DNAAF5 Antibody (PACO37374)
Antibody SKU:
PACO37374
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Dynein assembly factor 5, axonemal protein (621-843AA)
Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.
HEATR2: 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7p22.3Cellular Component: cytoplasmMolecular Function: dynein intermediate chain bindingBiological Process: cell projection organization and biogenesisDisease: Ciliary Dyskinesia, Primary, 18
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is essential for the preassembly or stability of axonemal dynein arms, and is found only in organisms with motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia-18, a disorder characterized by abnormalities of motile cilia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
