The DMRT3 Polyclonal Antibody (PAC016193) is a valuable tool for researchers studying the DMRT3 protein, a key regulator of neural development and function in the central nervous system. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the DMRT3 protein, researchers can effectively detect and analyze its expression in various cell types, facilitating investigations into neurobiology and neurodevelopmental disorders.DMRT3, also known as doublesex and mab-3 related transcription factor 3, is essential for proper neural circuit formation and function, playing a critical role in motor coordination and locomotion.
Dysregulation of DMRT3 has been implicated in neurological disorders such as spastic paraplegia and movement disorders. Therefore, studying the function of DMRT3 is crucial for gaining insights into neural development and potential therapeutic targets for neurodegenerative diseases.Overall, the DMRT3 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complexities of neural development and neurological disorders through the study of DMRT3 protein expression and function.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16193(DMRT3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO16193(DMRT3 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16193(DMRT3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT3 (doublesex and mab-3 related transcription factor 3), also known as DMRTA3, is a 472 amino acid, protein that contains one DM DNA-binding domain and belongs to the DMRT family. Localized to the nucleus, DMRT3 is expressed specifically in testis and is thought to regulate transcriptional events during early sexual development. The gene encoding DMRT3 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
Synonyms:
doublesex and mab-3 related transcription factor 3
