DMRT3 Antibody (PACO16193)
- SKU:
- PACO16193
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | DMRT3 Antibody (PACO16193) |
| Antibody SKU: | PACO16193 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human DMRT3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16193(DMRT3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO16193(DMRT3 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16193(DMRT3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT3 (doublesex and mab-3 related transcription factor 3), also known as DMRTA3, is a 472 amino acid, protein that contains one DM DNA-binding domain and belongs to the DMRT family. Localized to the nucleus, DMRT3 is expressed specifically in testis and is thought to regulate transcriptional events during early sexual development. The gene encoding DMRT3 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster. |
| Synonyms: | doublesex and mab-3 related transcription factor 3 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NQL9 |
| NCBI GenInfo Identifier: | 11056048 |
| NCBI Gene ID: | 58524 |
| NCBI Accession: | NP_067063.1 |
| UniProt Secondary Accession: | Q9NQL9,Q7LA03, Q7LCH8, Q96SC7, Q9NRQ9 |
| UniProt Related Accession: | Q9NQL9 |
| Molecular Weight: | 51,199 Da |
| NCBI Full Name: | doublesex- and mab-3-related transcription factor 3 |
| NCBI Synonym Full Names: | doublesex and mab-3 related transcription factor 3 |
| NCBI Official Symbol: | DMRT3Â Â |
| NCBI Official Synonym Symbols: | DMRTA3Â Â |
| NCBI Protein Information: | doublesex- and mab-3-related transcription factor 3; DMRT-like family A3; testis-specific protein |
| UniProt Protein Name: | Doublesex- and mab-3-related transcription factor 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Doublesex and mab-3 related transcription factor |
| UniProt Gene Name: | DMRT3Â Â |
| UniProt Entry Name: | DMRT3_HUMAN |
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