The DKC1 Polyclonal Antibody (CAB1862) is a valuable tool for researchers studying DKC1, a nucleolar protein associated with dyskeratosis congenita, a rare genetic disorder characterized by bone marrow failure and an increased risk of cancer. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in a variety of research applications including Western blotting.DKC1 plays a critical role in telomere maintenance and ribosomal RNA processing, making it a key player in cellular health and homeostasis. Dysregulation of DKC1 has been implicated in various diseases, including cancer and other genetic disorders.
Therefore, understanding the function and regulation of DKC1 is essential for developing targeted therapies and diagnostic tools for these conditions.By using the DKC1 Polyclonal Antibody, researchers can accurately detect and analyze DKC1 protein levels in different cell types, advancing our understanding of its role in disease pathogenesis. This antibody is a valuable resource for immunology and cancer research, with potential applications in drug development and personalized medicine.
Product Name:
DKC1 Rabbit Polyclonal Antibody
SKU:
CAB1862
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 245-514 of human DKC1 (NP_001354.1).
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1736
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using DKC1 Rabbit pAb (CAB1862) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
