DKC1 Rabbit Polyclonal Antibody (CAB1862)
- SKU:
- CAB1862
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | DKC1 Rabbit Polyclonal Antibody |
SKU: | CAB1862 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 245-514 of human DKC1 (NP_001354.1). |
Sequence: | ELRR VRSG VMSE KDHM VTMH DVLD AQWL YDNH KDES YLRR VVYP LEKL LTSH KRLV MKDS AVNA ICYG AKIM LPGV LRYE DGIE VNQE IVVI TTKG EAIC MAIA LMTT AVIS TCDH GIVA KIKR VIME RDTY PRKW GLGP KASQ KKLM IKQG LLDK HGKP TDST PATW KQEY VDYS ESAK KEVV AEVV KAPQ VVAE AAKT AKRK RESE SESD ETPP AAPQ LIKK EKKK SKKD KKAK AGLE SGAE PGDG DSDT TKKK KKKK KAKE VELV SE |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | DKC; CBF5; DKCX; NAP57; NOLA4; XAP101; DKC1 |
Positive Sample: | U-251MG,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cajal body, Cytoplasm, Nucleus, nucleolus. |
Calculated MW: | 58kDa |
Observed MW: | 43kDa |
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1736 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |