DIS3L2 Antibody (PACO37886)
- SKU:
- PACO37886
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DIS3L2 Antibody (PACO37886)
The DIS3L2 Polyclonal Antibody (PAC037886) is an essential tool for researchers studying DIS3L2, a key enzyme involved in RNA metabolism and degradation. This antibody, developed and validated for use in Western blot applications, is highly specific to DIS3L2 and provides accurate detection and analysis of the protein in various cellular contexts.DIS3L2 is a crucial component of the RNA exosome complex, responsible for degrading various RNA species to maintain cellular homeostasis. Dysregulation of DIS3L2 has been linked to several human diseases, including neurodegenerative disorders and cancer.
By targeting DIS3L2 with this antibody, researchers can gain insights into its function and potential therapeutic implications in these diseases.With its high specificity and sensitivity, the DIS3L2 Polyclonal Antibody is a valuable tool for researchers exploring the role of DIS3L2 in RNA metabolism, cellular homeostasis, and disease pathogenesis. Its versatility and reliability make it an ideal choice for studies in molecular biology, genetics, and cancer research.
| Antibody Name: | DIS3L2 Antibody (PACO37886) |
| Antibody SKU: | PACO37886 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DIS3-like exonuclease 2 protein (201-400AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human ovarian tissue using PACO37886 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human bladder cancer using PACO37886 at dilution of 1:100. |
| Background: | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
| Synonyms: | DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-), DIS3L2, FAM6A |
| UniProt Protein Function: | DIS3L2: Ribonuclease that plays a critical role in RNA metabolism. It is essential for correct mitosis, and negatively regulates cell proliferation. Defects in DIS3L2 are the cause of Perlman syndrome (PRLMNS). An autosomal recessive congenital overgrowth syndrome. Affected children are large at birth, are hypotonic, and show organomegaly, characteristic facial dysmorphisms (inverted V-shaped upper lip, prominent forehead, deep-set eyes, broad and flat nasal bridge, and low-set ears), renal anomalies (nephromegaly and hydronephrosis), frequent neurodevelopmental delay, and high neonatal mortality. Perlman syndrome is associated with a high risk of Wilms tumor. Histologic examination of the kidneys in affected children shows frequent nephroblastomatosis, which is a precursor lesion for Wilms tumor. Belongs to the RNR ribonuclease family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.13.-; Ribonuclease; Tumor suppressorChromosomal Location of Human Ortholog: 2q37.1Cellular Component: cytoplasm; nuclear exosome (RNase complex); polysomeMolecular Function: 3'-5'-exoribonuclease activity; magnesium ion binding; poly(U) binding; protein binding; ribonuclease activityBiological Process: cell division; mitosis; mitotic sister chromatid separation; mRNA catabolic process, exonucleolytic; negative regulation of cell proliferation; rRNA catabolic process; rRNA processing; stem cell maintenanceDisease: Perlman Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q8IYB7 |
| NCBI GenInfo Identifier: | 134288890 |
| NCBI Gene ID: | 129563 |
| NCBI Accession: | NP_689596 |
| UniProt Secondary Accession: | Q8IYB7,Q53S79, Q580W6, Q5XKH0, Q69YG5, Q6AW99, Q7Z4T6 Q8N9K9 |
| UniProt Related Accession: | Q8IYB7 |
| Molecular Weight: | Predicted: 97 kDaObserved: 94 kDa |
| NCBI Full Name: | DIS3-like exonuclease 2 isoform 1 |
| NCBI Synonym Full Names: | DIS3 like 3'-5' exoribonuclease 2 |
| NCBI Official Symbol: | DIS3L2Â Â |
| NCBI Official Synonym Symbols: | FAM6A; PRLMNS; hDIS3L2Â Â |
| NCBI Protein Information: | DIS3-like exonuclease 2 |
| UniProt Protein Name: | DIS3-like exonuclease 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | DIS3-like exonuclease |
| UniProt Gene Name: | DIS3L2Â Â |
| UniProt Entry Name: | DI3L2_HUMAN |
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