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Di-Methyl-Histone H2B (Lys5) Antibody (PACO00147)

SKU:
PACO00147
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Di-Methyl-Histone H2B (Lys5) Antibody (PACO00147)

The Di-Methyl Histone H2B Lys5 Antibody (PACO00147) is a valuable tool for researchers studying epigenetics and histone modifications. This polyclonal antibody, produced in rabbits, is highly specific and reactive towards the di-methylated form of histone H2B lysine 5 (H2B K5me2), a modification associated with gene regulation and chromatin structure.Validated for use in applications such as Western blotting and immunofluorescence, this antibody allows for the detection and analysis of H2B K5me2 in various cellular contexts. Its specificity towards this particular histone modification makes it ideal for studies on gene expression, chromatin remodeling, and epigenetic regulation.

Histone modifications, including di-methylation of H2B K5, play crucial roles in gene regulation and cellular processes. Understanding the function and dynamics of these modifications can provide insights into diseases such as cancer, developmental disorders, and neurodegenerative conditions. The Di-Methyl Histone H2B Lys5 Antibody offers researchers a powerful tool to investigate the roles of H2B K5me2 in epigenetic regulation and disease pathogenesis.

Antibody Name:Di-Methyl-Histone H2B (Lys5) Antibody
Antibody SKU:PACO00147
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthetic Peptide
Form:Liquid
Storage Buffer:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:Affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:HIST1H2BA; TSH2B; Histone H2B type 1-A; Histone H2B, testis; Testis-specific histone H2B; HIST1H2BB; H2BFF; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; H2B/f; HIST1H2BC; H2BFL; HIST1H2BE; H2BFH; HIST1H2BF; H2BFG; HIST1H2BG; H2BFA; HIST1H2BI; H2BFK
UniProt Protein Function:H2B1A: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Transcribed exclusively in testis, and the corresponding protein is also present in mature sperm. Belongs to the histone H2B family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p22.2Cellular Component: extrinsic to plasma membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: establishment and/or maintenance of chromatin architecture; inflammatory response; nucleosome assembly; nucleosome disassembly; plasminogen activation; positive regulation of binding; spermatogenesis, exchange of chromosomal proteins
UniProt Protein Details:
NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
UniProt Code:Q96A08
NCBI GenInfo Identifier:51316070
NCBI Gene ID:255626
NCBI Accession:Q96A08.3
UniProt Secondary Accession:Q96A08,Q6NZ98, Q6NZA0, Q6NZA1, B2R544
UniProt Related Accession:Q96A08
Molecular Weight:14,167 Da
NCBI Full Name:Histone H2B type 1-A
NCBI Synonym Full Names:histone cluster 1, H2ba
NCBI Official Symbol:HIST1H2BA  
NCBI Official Synonym Symbols:STBP; TH2B; H2BFU; TSH2B; TSH2B.1; bA317E16.3  
NCBI Protein Information:histone H2B type 1-A
UniProt Protein Name:Histone H2B type 1-A
UniProt Synonym Protein Names:Histone H2B, testis; TSH2B.1; Testis-specific histone H2B
Protein Family:Histone
UniProt Gene Name:HIST1H2BA  
UniProt Entry Name:H2B1A_HUMAN

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