The DGCR14 Polyclonal Antibody (CAB13174) is a valuable tool for researchers studying the DGCR14 protein, which is implicated in genetic disorders and developmental delays. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the DGCR14 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it well-suited for investigations in genetics and developmental biology.DGCR14, also known as DiGeorge syndrome critical region gene 14, plays a crucial role in the development and functioning of multiple organ systems.
Its involvement in genetic syndromes like DiGeorge syndrome highlights its significance in human health and disease. Research on DGCR14 is essential for gaining insights into the molecular mechanisms underlying developmental disorders and may lead to potential therapeutic targets for related conditions.Overall, the DGCR14 Polyclonal Antibody offers researchers a high-quality tool for studying the role of DGCR14 in genetic disorders and developmental delays, paving the way for new advancements in the field of molecular biology and genetics.
Product Name:
DGCR14 Rabbit Polyclonal Antibody
SKU:
CAB13174
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DGCR14 (NP_073210.1).
This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8220
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DGCR14 Rabbit pAb (CAB13174) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
