The DEUP1 Polyclonal Antibody (PAC060649) is a valuable tool for researchers studying DEUP1, a protein involved in DNA repair and cell cycle regulation. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples. By binding to the DEUP1 protein, this antibody enables the detection and analysis of DEUP1 levels in various cell types.DEUP1 plays a crucial role in maintaining genomic stability and ensuring accurate cell division. Dysregulation of DEUP1 has been implicated in diseases such as cancer, where defects in DNA repair mechanisms can lead to uncontrolled cell growth.
By studying the function of DEUP1, researchers can gain insights into the molecular pathways underlying cancer development and potentially identify new therapeutic targets.Overall, the DEUP1 Polyclonal Antibody is a valuable tool for investigating the role of DEUP1 in DNA repair mechanisms and its potential implications for disease progression. Its high reactivity and specificity make it a reliable choice for researchers in the fields of cancer biology, genetics, and cell biology.
Antibody Name:
DEUP1 Antibody (PACO60649)
Antibody SKU:
PACO60649
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Deuterosome assembly protein 1 protein (217-292AA)
IHC image of PACO60649 diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).
Synonyms:
Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67), DEUP1, CCDC67
