The DEGS1 Polyclonal Antibody (CAB12648) is an essential tool for researchers studying DEGS1, a key enzyme in sphingolipid metabolism that plays a crucial role in cell growth and survival. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for Western blot applications. With the ability to specifically bind to the DEGS1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in lipid metabolism and cancer research.
DEGS1, also known as dihydroceramide desaturase 1, is involved in the synthesis of ceramides, which are important signaling molecules in regulating cell proliferation, differentiation, and cell death. Dysregulation of DEGS1 activity has been implicated in various diseases, including cancer, metabolic disorders, and neurodegenerative diseases. By gaining insights into the functions of DEGS1, researchers can potentially identify novel therapeutic targets for treating these conditions and advancing our knowledge of lipid biology.
Product Name:
DEGS1 Rabbit Polyclonal Antibody
SKU:
CAB12648
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 234-323 of human DEGS1 (NP_003667.1).
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.
Purification Method:
Affinity purification
Gene ID:
8560
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DEGS1 Rabbit pAb (CAB12648) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
