The DDX39A Polyclonal Antibody (CAB7955) is a valuable tool for researchers studying DDX39A, a protein involved in RNA splicing and processing. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot experiments. By targeting the DDX39A protein, this antibody enables accurate detection and analysis of RNA splicing events in various cell types, making it an essential component in studies related to gene expression regulation and RNA metabolism.DDX39A, also known as UAP56, plays a critical role in facilitating the assembly of spliceosomal complexes, which are essential for mRNA splicing and processing.
Dysregulation of DDX39A has been linked to various diseases, including cancer, neurodevelopmental disorders, and viral infections. Therefore, the investigation of DDX39A function is instrumental in understanding the molecular mechanisms underlying these pathological conditions and in developing potential therapeutic strategies targeting RNA processing pathways.Overall, the DDX39A Polyclonal Antibody is a valuable research tool for scientists interested in unraveling the intricacies of RNA processing and its implications in health and disease. Its high specificity and versatility make it an indispensable asset for studies in molecular biology, genomics, and biomedical research.
Product Name:
DDX39A Rabbit Polyclonal Antibody
SKU:
CAB7955
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DDX39A (NP_005795.2).
This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
10212
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using DDX39A Rabbit pAb (CAB7955) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
