DDX19B Antibody (PACO16167)
- SKU:
- PACO16167
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DDX19B Antibody (PACO16167)
The DDX19B Polyclonal Antibody (PACO16167) is a valuable tool for researchers studying DDX19B, a protein involved in RNA processing and transport within the cell. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications.DDX19B, a member of the DEAD-box RNA helicase family, plays a crucial role in RNA metabolism by facilitating the transport of mRNA molecules from the nucleus to the cytoplasm. Dysregulation of DDX19B has been implicated in various diseases, including cancer and viral infections, highlighting its potential as a therapeutic target.
By utilizing the DDX19B Polyclonal Antibody, researchers can investigate the expression levels and localization of DDX19B in different cell types, offering insights into its function and potential role in disease pathogenesis. This antibody is a valuable tool for studies in molecular biology, virology, and cancer research, contributing to the advancement of knowledge in these fields.
| Antibody Name: | DDX19B Antibody (PACO16167) |
| Antibody SKU: | PACO16167 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human DDX19B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16167(DDX19B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO16167(DDX19B Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16167(DDX19B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B |
| UniProt Protein Function: | DDX19B: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.13; Helicase; RNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleusMolecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; RNA bindingBiological Process: mRNA export from nucleus; protein transport; RNA secondary structure unwinding |
| UniProt Protein Details: | |
| NCBI Summary: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UMR2 |
| NCBI GenInfo Identifier: | 10719979 |
| NCBI Gene ID: | 11269 |
| NCBI Accession: | Q9UMR2.1 |
| UniProt Secondary Accession: | Q9UMR2,Q6FIB7, Q6IAE0, Q96KE7, Q9H0U0, B3KNE9, B4DXS6 E7EMK4 |
| UniProt Related Accession: | Q9UMR2 |
| Molecular Weight: | 51,063 Da |
| NCBI Full Name: | ATP-dependent RNA helicase DDX19B |
| NCBI Synonym Full Names: | DEAD-box helicase 19B |
| NCBI Official Symbol: | DDX19BÂ Â |
| NCBI Official Synonym Symbols: | DBP5; RNAh; DDX19Â Â |
| NCBI Protein Information: | ATP-dependent RNA helicase DDX19B |
| UniProt Protein Name: | ATP-dependent RNA helicase DDX19B |
| UniProt Synonym Protein Names: | DEAD box RNA helicase DEAD5; DEAD box protein 19B |
| Protein Family: | ATP-dependent RNA helicase |
| UniProt Gene Name: | DDX19BÂ Â |
| UniProt Entry Name: | DD19B_HUMAN |
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