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DCTN4 Antibody (PACO42542)

SKU:
PACO42542
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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DCTN4 Antibody (PACO42542)

The DCTN4 Polyclonal Antibody (PAC042542) is a valuable tool for researchers studying the DCTN4 protein, which plays a crucial role in cellular processes such as intracellular trafficking and protein transport. This antibody, produced in rabbits, has been shown to exhibit high reactivity with human samples and is suitable for use in Western blot applications for the detection and analysis of DCTN4 in various cell types.DCTN4, also known as dynactin subunit 4, is involved in the dynein-dynactin motor complex which mediates retrograde transport along microtubules.

Dysfunction of DCTN4 has been implicated in diseases such as neurodegenerative disorders and cancer, making it an important target for further research. By understanding the role of DCTN4 in cellular processes, researchers can gain insights into potential therapeutic strategies for these conditions.

Antibody Name:DCTN4 Antibody (PACO42542)
Antibody SKU:PACO42542
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:Human
Immunogen:Recombinant Human Dynactin subunit 4 protein (2-460AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: HepG2 whole cell lysate, Jurkat whole cell lysate, HEK293 whole cell lysate, SH-SY5Y whole cell lysate. All lanes: DCTN4 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53, 46, 54 kDa. Observed band size: 53 kDa.
Background:Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Synonyms:Dynactin subunit 4 (Dyn4) (Dynactin subunit p62), DCTN4
UniProt Protein Function:dynactin 4: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Belongs to the dynactin subunit 4 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-bindingChromosomal Location of Human Ortholog: 5q33.1Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynactin complex; nucleusMolecular Function: protein binding; protein N-terminus bindingBiological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; nuclear migration
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9UJW0
NCBI GenInfo Identifier:62900106
NCBI Gene ID:51164
NCBI Accession:Q9UJW0.1
UniProt Secondary Accession:Q9UJW0,Q8TAN8, B3KWW0, D3DQH0, E5RGT5
UniProt Related Accession:Q9UJW0
Molecular Weight:53,152 Da
NCBI Full Name:Dynactin subunit 4
NCBI Synonym Full Names:dynactin subunit 4
NCBI Official Symbol:DCTN4  
NCBI Official Synonym Symbols:P62; DYN4  
NCBI Protein Information:dynactin subunit 4
UniProt Protein Name:Dynactin subunit 4
UniProt Synonym Protein Names:Dynactin subunit p62
Protein Family:Dynactin
UniProt Gene Name:DCTN4  
UniProt Entry Name:DCTN4_HUMAN
Antibodies
DCTN4 Antibody (PACO08765)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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