The DBH Polyclonal Antibody (CAB13971) is specifically designed for research involving dopamine beta-hydroxylase (DBH), an enzyme responsible for the conversion of dopamine to norepinephrine. This antibody, raised in rabbits, shows high reactivity with human, mouse, and rat samples, making it versatile for a variety of experimental settings.DBH is a crucial enzyme in the regulation of catecholamine neurotransmitters, impacting a range of physiological processes including cognition, emotion, and cardiovascular function. Dysregulation of DBH activity has been implicated in various diseases such as neurodegenerative disorders, psychiatric conditions, and cardiovascular diseases, making this antibody a valuable tool for researchers in these fields.
Validated for use in Western blot and immunohistochemistry applications, the DBH Polyclonal Antibody binds specifically to the DBH protein, allowing for accurate detection and analysis in different tissues and cell types. Its high specificity and sensitivity make it an ideal choice for studies focusing on neurotransmitter metabolism, neurobiology, and disease mechanisms related to DBH dysfunction.
Product Name:
DBH Rabbit Polyclonal Antibody
SKU:
CAB13971
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3).
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
Purification Method:
Affinity purification
Gene ID:
1621
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human liver using DBH Rabbit pAb (CAB13971) at dilution of 1:200 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
