The CYP3A7 Polyclonal Antibody (PAC022778) is a valuable tool for researchers studying the cytochrome P450 family of enzymes, specifically CYP3A7. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. It binds specifically to the CYP3A7 protein, allowing for accurate detection and analysis in a variety of cell types.CYP3A7 is a key enzyme involved in drug metabolism and plays a crucial role in the detoxification and elimination of foreign compounds from the body. Additionally, CYP3A7 is known to be highly expressed in fetal liver and is important for the metabolism of steroids during development.
Research into CYP3A7 can provide valuable insights into drug metabolism, toxicology, and developmental biology.By utilizing the CYP3A7 Polyclonal Antibody, researchers can further investigate the function and regulation of this important enzyme, leading to a better understanding of its role in human health and disease. This antibody is an essential tool for studies exploring drug metabolism, liver development, and the impact of genetic variations on CYP3A7 activity.
Antibody Name:
CYP3A7 Antibody (PACO22778)
Antibody SKU:
PACO22778
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human Cytochrome P450 3A7.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from LOVO cells, using Cytochrome P450 3A7 antibody.
Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3AP1 pseudogene and is represented by GeneID:100861540.
Synonyms:
Cytochrome P450; family 3; subfamily A; polypeptide 7; CYP3A7
UniProt Protein Function:
CYP3A7: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family.Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1Chromosomal Location of Human Ortholog: 7q22.1Cellular Component: endoplasmic reticulum membraneMolecular Function: iron ion binding; heme binding; oxygen binding; monooxygenase activityBiological Process: xenobiotic metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]
